Thursday, March 27, 2008

What are the Two main types of Genetic Engineering?

There are two main types of genetic engineering. Somatic modifications involve adding genes to cells other than egg or sperm cells. For example, if a person had a disease caused by a defective gene, a healthy gene could be added to the affected cells to treat the disorder. The distinguishing characteristic of somatic engineering is that it is non-inheritable, e.g. the new gene would not be passed to the recipient’s offspring.
Germline engineering would change genes in eggs, sperm, or very early embryos. This type of engineering is inheritable, meaning that the modified genes would appear not only in any children that resulted from the procedure, but in all succeeding generations. This application is by far the more consequential as it could open the door to the perpetual and irreversible alteration of the human species.
There are two techniques researchers are currently experimenting with:
Viruses are good at injecting their DNA payload into human cells and reproducing it. By adding the desired DNA to the DNA of non-pathogenic virus, a small amount of virus will reproduce the desired DNA and spread it all over the body.
Manufacture large quantities of DNA, and somehow package it to induce the target cells to accept it, either as an addition to one of the original 23 chromosomes, or as an independent 24th human artificial chromosome.
Human genetic engineering means that some part of the genes or DNA of a person are changed. It is possible that through engineering, people could be given more arms, bigger brains, or other structural alteration such as fins if desired. A more common type of change would be finding the genes of extraordinary people - such as those for intelligence, stamina, longevity, and incorporating those in embryos. Human genetic engineering holds the promise of being able to cure diseases and increasing the immunity of people to virus. Disorders such as Cystic fibrosis, which is a genetic disease that affects lungs and other organs is the result of small DNA changes.

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